As of late 2020, yes. Samsung devices running Android 9.0 or later support Google zero-touch enrolment alongside Samsung's own Knox Mobile Enrolment (KME) service.
Both achieve the same outcome - a device that enrols into the organisation's EMM without manual intervention at first boot. The differences are in features and scope:
Zero-touch is OEM-agnostic and managed through the zero-touch portal. For organisations with mixed-OEM fleets, it provides a single provisioning workflow across Samsung, Pixel, and other supported devices.
KME is Samsung-specific and has been available longer for Android Enterprise provisioning (since Knox 2.8). It offers additional capabilities over zero-touch, including:
KME is free to use, though some optional advanced settings require a Knox Suite licence. Devices must be purchased through a KME-supported reseller to be registered in the KME portal.
For a Samsung-only fleet, KME is the more feature-rich option. For mixed-OEM fleets, zero-touch provides consistency. Both support fully managed, dedicated, and COPE deployments. Zero-touch provisions company-owned devices only - it does not support personally-owned (BYOD) work profile enrolment. KME supports work profile enrolment for both company-owned and BYOD scenarios.
Configuring both KME and zero-touch on the same Samsung device is not supported. It can cause configuration conflicts and out-of-sync states that are difficult to debug. Pick one method per device.
For more on Samsung's broader enterprise capabilities, see Does Samsung support Android Enterprise?.