Yes, in certain circumstances.
Google Play Protect runs on all GMS-certified Android devices, including those under enterprise management. If Play Protect identifies an app as potentially harmful, it can:
This applies regardless of how the app was installed - including apps pushed by the EMM or sideloaded as part of an enterprise workflow. On managed devices, this can disrupt critical business applications if Play Protect flags them incorrectly.
What can administrators do?
Play Protect's cloud scanning of sideloaded apps on managed devices was removed in September 2024, but on-device detection continues. See the related FAQ: Has Play Protect changed how it handles sideloaded apps on managed devices?.