No. Picture-in-Picture (PiP) mode does not function when a device is in lock task (kiosk) mode.
When an application calls enterPictureInPictureMode() on a device with lock task active, the request is silently ignored. This is by design - lock task mode restricts the device to a controlled set of applications and prevents system UI elements that could allow users to navigate away from the kiosk experience.
Common enterprise use cases affected include:
There is no official workaround within the standard lock task API. Some options organisations have explored:
This is an active area of community feedback. Google has not indicated whether PiP support in lock task mode is planned.